Semaglutide for Weight Loss: What to Expect in Your First 90 Days

If you’re considering Semaglutide for weight loss, you’re not alone. This groundbreaking treatment has helped many people shed stubborn weight and improve their overall health. But what does the first 90 days look like? Let’s break down what you can expect—week by week—along with tips for maximizing your results and addressing common concerns.

How Semaglutide Works

Semaglutide is a GLP-1 receptor agonist that mimics a hormone in your body responsible for regulating appetite and blood sugar. It helps with weight loss by:

• Reducing hunger – You feel fuller faster, leading to smaller portion sizes.

• Slowing digestion – Food stays in your stomach longer, keeping cravings at bay.

• Improving insulin sensitivity – Helps regulate blood sugar, reducing fat storage.

Your First 90 Days on Semaglutide: What to Expect

Weeks 1-4: Getting Started

• What’s Happening: Your body is adjusting to the medication. You may experience a reduced appetite early on, but weight loss might be gradual. Some people report mild nausea as their body adapts or if eating incorrectly.

• Expected Results: 2-5 pounds lost, primarily from water weight and reduced calorie intake.

• Tips for Success:

  • Start with small, protein-rich meals to prevent nausea.

  • Stay hydrated—water helps with digestion and energy.

  • Begin light exercise, like walking, to support metabolism.

Weeks 5-8: Progress Kicks In

• What’s Happening: Your dosage increases and appetite suppression is more noticeable. You’re likely eating smaller portions naturally.

• Expected Results: 5-10 pounds lost, with fat loss becoming more apparent.

• Tips for Success:

  • Focus on whole, nutrient-dense foods to fuel your body.

  • Prioritize protein and water to stay full longer.

  • Continue building an exercise routine—strength training can enhance fat loss.

Weeks 9-12: Major Changes & Momentum

• What’s Happening: By now, your body has adjusted, and weight loss is typically more consistent. Many people feel increased energy and improved metabolism.

• Expected Results: 10-15+ pounds lost, with visible changes in body composition.

• Tips for Success:

  • Maintain healthy habits—semaglutide works best with lifestyle changes.

  • Track progress with measurements, not just the scale.

  • Stay consistent—results continue with long-term commitment.

Common Concerns & How to Handle Them

“Will I feel sick?”

Some people experience nausea or mild digestive discomfort, but this usually improves over time. Eating smaller, protein filled meals and staying hydrated can help.

“Can I eat normally?”

Yes! But focusing on high-quality foods will maximize results. Avoid processed food, high fat foods,  and excessive sugar to prevent blood sugar spikes.

“Will I regain weight if I stop?”

Long-term weight management depends on sustaining healthy habits. Many people transition to a maintenance plan with diet, exercise, and lifestyle support. 

There is also an option to do a maintenance dose.

Final Thoughts

Semaglutide can be a powerful tool for weight loss, but it’s most effective when combined with healthy eating, movement, and consistency. If you’re starting your journey, be patient with yourself, and celebrate every milestone!

Interested in Semaglutide for weight loss? Full Circle Health and Wellness offers personalized weight loss programs to help you achieve your goals. Schedule a consultation today!